SmartGene
STAR PipelineDog

STAR-K9E

Canine obesity · Caninized GLP-1 receptor agonist · once-weekly subcutaneous (target product profile)

Overview

Species
Dog
Indication
Canine obesity
Target
GLP-1 receptor
Modality
Caninized GLP-1 receptor agonist · once-weekly subcutaneous (target product profile)
Current Stage
Cell Line
Route
Lead pipeline · own approval
Own Approval

Why It Matters

A Category with No Approved GLP-1 Therapy

59% of US dogs are overweight or obese (APOP 2022 survey), yet no companion-animal GLP-1 receptor agonist has been approved. SmartGene caninizes a GLP-1 mechanism already validated in humans, with once-weekly dosing as the target product profile.

59%

US dogs overweight or obese (APOP 2022)

0

Approved companion-animal GLP-1 receptor agonists

Mechanism of action

Fig. 1
GLP-1 receptor agonist acting on the brain, stomach and pancreas
Fig. 1. A once-weekly GLP-1 receptor agonist acts at GLP-1 receptors in the brain, stomach and pancreas to regulate appetite and glucose. Conceptual; in vivo efficacy is not yet established.

Partnering

Co-Development Partners · Territory-Exclusive Licensees at Efficacy POC

Measured in vitro data is on file for binding, expression and canine-cell engagement. The full package is available under an executed CDA, and co-development is open from the current stage.

Every programme is in development and pre-approval. Product properties, including dosing interval and efficacy endpoints, are development targets and have not been established in vivo. Technical, market and development detail is available under an executed CDA.